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Antidepressants are drugs used for the treatment of major depressive disorders as well as other conditions including anxiety disorders, obsessive compulsive disorders (OCD), eating disorders, insomnia, post-traumatic stress disorder and some chronic pain. Most antidepressants act by increasing the synaptic availability of serotonin, norepinephrine, or dopamine. This pharmacology lecture covers topics such as monoamine hypothesis of depression, bipolar disorder, role of serotonin, norepinephrine, dopamine, monoamine receptors, mechanism of action of antidepressants; selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), atypical antidepressants, and Lithium. Antidepressants mentioned include: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Maprotiline, Nortriptyline, Protriptyline, Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline, Bupropion, Mirtazapine, Trazodone, Nefazodone, Vilazodone, and Vortioxetine.