Antiarrhythmics are drugs that are used to treat abnormal rhythms of the heart, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. In general, antiarrhythmic drugs work by suppressing abnormal impulse formation, suppressing abnormal impulse conduction, or prolonging effective refractory periods. This pharmacology lecture covers topics such as cardiac conduction system: SA node, AV node, bundle of His, bundle branches, purkinje fibers, cardiac action potential, pacemaker cells, conducting cells, contractile cells; mechanisms of arrhythmias, bradycardia, tachycardia, abnormal automaticity, triggered activity, Wolff–Parkinson–White syndrome, atrioventricular nodal reentry tachycardia, Vaughan-Williams classification, class I (A, B, C), class II, class III, class IV antiarrhythmic drugs. Antiarrhythmics mentioned include: Procainamide, Quinidine, Disopyramide, Lidocaine, Mexiletine, Flecainide, Propafenone, Propranolol, Metoprolol, Atenolol, Esmolol, Amiodarone, Dronedarone, Sotalol, Dofetilide, Ibutilide, Verapamil, Diltiazem, Digoxin, Adenosine, and Magnesium Sulfate.
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